[HTML][HTML] Biologic functions of the IFN‐γ receptors

G Tau, P Rothman - Allergy, 1999 - ncbi.nlm.nih.gov
G Tau, P Rothman
Allergy, 1999ncbi.nlm.nih.gov
Interferon-gamma (IFN-c) is a cytokine that plays an important role in inducing and
modulating an array of immune responses. Cellular responses to IFN-c are mediated by its
heterodimeric cell-surface receptor (IFN-cR), which activates downstream signal
transduction cascades, ultimately leading to the regulation of gene expression. In order to
study the role of IFN-c in a number of immune responses and pathways, researchers have
generated mice with altered patterns of IFN-cR gene expression. These studies, together …
Interferon-gamma (IFN-c) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN-c are mediated by its heterodimeric cell-surface receptor (IFN-cR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression. In order to study the role of IFN-c in a number of immune responses and pathways, researchers have generated mice with altered patterns of IFN-cR gene expression. These studies, together with analyses of naturally occurring mutations of the IFN-cR in man, have been instrumental in elucidating the diverse functions of IFN-c, and are the subject of this review.
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