Unlike the non-renin-dependent hypertension associated with infrarenal aorta banding, an
abnormal accumulation of fibrillar collagen occurs within the adventitia of intramural
coronary arteries and neighboring interstitial space of the left and right ventricles in arterial
hypertension associated with primary or secondary hyperaldosteronism. Based on these
findings it was suggested that this interstitial and perivascular fibrosis was mediated by
mineralocorticold excess (ie, elevated plasma aldosterone relative to dietary sodium) and …