Recently, attention has been focused on the role of aldosterone in the pathophysiology of
hypertension and cardiovascular disease. Several clinical and experimental data support
the hypothesis that aldosterone contributes to the progression of renal injury. However, the
molecular mechanisms of the effects of aldosterone in signal transduction and the cell-cycle
progression of mesangial cells are not well known. For determining the signaling pathway of
aldosterone in cultured mesangial cells, the effects of aldosterone on the mitogen-activated …