Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
W Aoi, N Niisato, Y Sawabe, H Miyazaki… - Cell biology …, 2007 - Elsevier
Epithelial sodium channel (ENaC) plays a crucial role in controlling sodium reabsorption in
the kidney keeping the normal blood pressure. We previously reported that the expression of
ENaC mRNA in the kidney of Dahl salt-sensitive (DS) rats was abnormally regulated by
aldosterone, however it is unknown if dietary sodium affects the expression of ENaC and
serum and glucocorticoid-regulated kinase 1 (SGK1), which plays an important role in ENaC
activation, in DS rats. In the present study, we investigated whether dietary sodium …
the kidney keeping the normal blood pressure. We previously reported that the expression of
ENaC mRNA in the kidney of Dahl salt-sensitive (DS) rats was abnormally regulated by
aldosterone, however it is unknown if dietary sodium affects the expression of ENaC and
serum and glucocorticoid-regulated kinase 1 (SGK1), which plays an important role in ENaC
activation, in DS rats. In the present study, we investigated whether dietary sodium …