Tumor progression in epithelial tissues is characterized by a series of genetic and
epigenetic changes that lead ultimately to metastasis. Alterations in E-cadherin and its
cytoplasmic regulators, the catenins, have been implicated as central to this process. Here,
we focus on p120-catenin and its rising incidence in the pathology literature as a molecule
altered in human tumors. The data show that p120 is frequently altered and/or lost in tumors
of the colon, bladder, stomach, breast, prostate, lung, and pancreas. Moreover, in some …