[HTML][HTML] A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids
DM Shih, HR Kast-Woelbern, J Wong, YR Xia… - Journal of lipid …, 2006 - ASBMB
Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is
secreted by the liver and transported in the blood complexed to HDL. In humans and mice,
low plasma levels of PON1 have also been linked to the development of atherosclerosis. We
previously reported that hepatic Pon1 expression was decreased when C57BL/6J mice
were fed a high-fat, high-cholesterol diet supplemented with cholic acid (CA). In the current
study, we used wild-type and farnesoid X receptor (FXR) null mice to demonstrate that this …
secreted by the liver and transported in the blood complexed to HDL. In humans and mice,
low plasma levels of PON1 have also been linked to the development of atherosclerosis. We
previously reported that hepatic Pon1 expression was decreased when C57BL/6J mice
were fed a high-fat, high-cholesterol diet supplemented with cholic acid (CA). In the current
study, we used wild-type and farnesoid X receptor (FXR) null mice to demonstrate that this …