Molecular regulation of lung development

WV Cardoso - Annual review of physiology, 2001 - annualreviews.org
WV Cardoso
Annual review of physiology, 2001annualreviews.org
▪ Abstract There is increasing evidence suggesting that formation of the tracheobronchial
tree and alveoli results from heterogeneity of the epithelial-mesenchymal interactions along
the developing respiratory tract. Recent genetic data support this idea and show that this
heterogeneity is likely the result of activation of distinct networks of signaling molecules
along the proximal-distal axis. Among these signals, fibroblast growth factors, retinoids,
Sonic hedgehog, and transforming growth factors appear to play prominent roles. We …
Abstract
There is increasing evidence suggesting that formation of the tracheobronchial tree and alveoli results from heterogeneity of the epithelial-mesenchymal interactions along the developing respiratory tract. Recent genetic data support this idea and show that this heterogeneity is likely the result of activation of distinct networks of signaling molecules along the proximal-distal axis. Among these signals, fibroblast growth factors, retinoids, Sonic hedgehog, and transforming growth factors appear to play prominent roles. We discuss how these and other pattern regulators may be involved in initiation, branching, and differentiation of the respiratory system.
Annual Reviews