The isoprostanes: unique bioactive products of lipid peroxidation

JD Morrow, LJ Roberts - Progress in lipid research, 1997 - Elsevier
Free radicals, principally derived from oxygen, have been implicated in the pathophysiology
of a wide variety of human diseases including cancer, atherosclerosis, neurodegenerative
disorders and even the normal aging process./-4 Definitive evidence for this association is
often lacking, however, because of recognized shortcomings with methods to assess
oxidative stress status in vivo)