[HTML][HTML] ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis
CW Joyce, EM Wagner, F Basso, MJ Amar… - Journal of Biological …, 2006 - ASBMB
The identification of ABCA1 as a key transporter responsible for cellular lipid efflux has led to
considerable interest in defining its role in cholesterol metabolism and atherosclerosis. In
this study, the effect of overexpressing ABCA1 in the liver of LDLr-KO mice was investigated.
Compared with LDLr-KO mice, ABCA1-Tg× LDLr-KO (ABCA1-Tg) mice had significantly
increased plasma cholesterol levels, mostly because of a 2.8-fold increase in cholesterol
associated with a large pool of apoB-lipoproteins. ApoB synthesis was unchanged but the …
considerable interest in defining its role in cholesterol metabolism and atherosclerosis. In
this study, the effect of overexpressing ABCA1 in the liver of LDLr-KO mice was investigated.
Compared with LDLr-KO mice, ABCA1-Tg× LDLr-KO (ABCA1-Tg) mice had significantly
increased plasma cholesterol levels, mostly because of a 2.8-fold increase in cholesterol
associated with a large pool of apoB-lipoproteins. ApoB synthesis was unchanged but the …