Human apolipoprotein AI gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.
AS Plump, CJ Scott, JL Breslow - Proceedings of the …, 1994 - National Acad Sciences
AS Plump, CJ Scott, JL Breslow
Proceedings of the National Academy of Sciences, 1994•National Acad SciencesAtherosclerosis is a complex disease with both genetic and environmental determinants.
Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to
atherosclerosis. In order to assess the role of human apolipoprotein (hApo) AI and high
density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing
the hApo AI gene were crossed with Apo E-deficient mice. Apo E-/-, hApo AI mice with two-
fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less …
Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to
atherosclerosis. In order to assess the role of human apolipoprotein (hApo) AI and high
density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing
the hApo AI gene were crossed with Apo E-deficient mice. Apo E-/-, hApo AI mice with two-
fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less …
Atherosclerosis is a complex disease with both genetic and environmental determinants. Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to atherosclerosis. In order to assess the role of human apolipoprotein (hApo) A-I and high density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing the hApo A-I gene were crossed with Apo E-deficient mice. Apo E-/-, hApo A-I mice with two-fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less fibroproliferative lesions by 8 months of age. A strong reciprocal relationship between HDL cholesterol levels and atherosclerosis was found with HDL levels accounting for 78% of the observed variance in mean lesion area. The effect of HDL on atherosclerosis resistance was independent of non-HDL cholesterol.
National Acad Sciences