Size series of small indium arsenide− zinc selenide core− shell nanocrystals and their application to in vivo imaging

JP Zimmer, SW Kim, S Ohnishi, E Tanaka… - Journal of the …, 2006 - ACS Publications
JP Zimmer, SW Kim, S Ohnishi, E Tanaka, JV Frangioni, MG Bawendi
Journal of the American Chemical Society, 2006ACS Publications
We have developed a size series of unusually small, water-soluble (InAs) ZnSe (core) shell
quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including
multiple sequential lymph node mapping and extravasation from the vasculature. The
biological utility of these fluorescent probes resulted from our intentional choice to match the
semiconductor material and water-soluble ligand with a desired final hydrodynamic
diameter and emission wavelength.
We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength.
ACS Publications