[HTML][HTML] Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
K Yoshida, H Liu, Y Miki - Journal of Biological Chemistry, 2006 - ASBMB
The p53 tumor suppressor is activated in the cellular response to genotoxic stress.
Transactivation of p53 target genes dictates cell cycle arrest and DNA repair or induction of
apoptosis; however, a molecular mechanism responsible for these distinct functions remains
unclear. Recent studies revealed that phosphorylation of p53 on Ser 46 was associated with
induction of p53AIP1 expression, resulting in the commitment of the cell fate into apoptotic
cell death. Moreover, upon exposure to genotoxic stress, p53DINP1 was expressed and …
Transactivation of p53 target genes dictates cell cycle arrest and DNA repair or induction of
apoptosis; however, a molecular mechanism responsible for these distinct functions remains
unclear. Recent studies revealed that phosphorylation of p53 on Ser 46 was associated with
induction of p53AIP1 expression, resulting in the commitment of the cell fate into apoptotic
cell death. Moreover, upon exposure to genotoxic stress, p53DINP1 was expressed and …