The role of CD4+ CD25+ regulatory T cells in viral infections
TW Vahlenkamp, MB Tompkins… - Veterinary immunology and …, 2005 - Elsevier
Many virus infections result in the suppression of one or more functions of the immune
system. Multiple mechanisms have been proposed to explain viral-induced
immunosuppression, including an imbalance in the cellular Th1/Th2 or cytokine profile,
induction of anergy, depletion of effector cells and most recently the activation of CD4+
CD25+ regulatory T (T reg) cells. CD4+ CD25+ T reg cells are a subset of circulating CD4+ T
cells with suppressive properties. CD4+ CD25+ T reg cells were first identified in mice as …
system. Multiple mechanisms have been proposed to explain viral-induced
immunosuppression, including an imbalance in the cellular Th1/Th2 or cytokine profile,
induction of anergy, depletion of effector cells and most recently the activation of CD4+
CD25+ regulatory T (T reg) cells. CD4+ CD25+ T reg cells are a subset of circulating CD4+ T
cells with suppressive properties. CD4+ CD25+ T reg cells were first identified in mice as …