[HTML][HTML] Differential effect on U937 cell differentiation by targeting transcriptional factors implicated in tissue-or stage-specific induced integrin expression
A Garcı́a, A Serrano, E Abril, P Jimenez, LM Real… - Experimental …, 1999 - Elsevier
The inhibition of transcription factor functions was used to define their role in phorbol ester-
induced cellular differentiation of a monocytic cell line, U937. We demonstrate a differential
effect on cell adhesion and differentiation: antisense or competitive binding with double-
stranded oligonucleotides antagonized the functions of AP-1, NF-κB, and PU. 1
transcriptional factors. In the presence of phorbol 12-myristate 13-acetate (PMA), U937 cells
attached to the plastic surface and cells were characterized by marked expression of β2 …
induced cellular differentiation of a monocytic cell line, U937. We demonstrate a differential
effect on cell adhesion and differentiation: antisense or competitive binding with double-
stranded oligonucleotides antagonized the functions of AP-1, NF-κB, and PU. 1
transcriptional factors. In the presence of phorbol 12-myristate 13-acetate (PMA), U937 cells
attached to the plastic surface and cells were characterized by marked expression of β2 …