[HTML][HTML] VentX trans-activates p53 and p16ink4a to regulate cellular senescence
X Wu, H Gao, W Ke, M Hager, S Xiao… - Journal of Biological …, 2011 - ASBMB
Cell senescence is a process of irreversible arrest of cell proliferation and plays an important
role in tumor suppression. Recent studies showed that Wnt inhibition is a trigger of cellular
senescence. Using methods of reverse genetics, we recently identified VentX, a human
homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt
repressor and a putative tumor suppressor in lymphocytic leukemia. Here, we show that
VentX is a direct transcriptional activator of p53-p21 and p16 ink4a-Rb tumor suppression …
role in tumor suppression. Recent studies showed that Wnt inhibition is a trigger of cellular
senescence. Using methods of reverse genetics, we recently identified VentX, a human
homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt
repressor and a putative tumor suppressor in lymphocytic leukemia. Here, we show that
VentX is a direct transcriptional activator of p53-p21 and p16 ink4a-Rb tumor suppression …