[HTML][HTML] Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines
L Li, PE Shaw - Journal of Biological Chemistry, 2002 - ASBMB
The intracellular signals driving the proliferation of breast carcinoma (BC) cells have been
widely studied. Both the mitotic and metastatic potential of BC cells have been linked to the
frequent overexpression of ErbB family members. Other signaling molecules, including the
estrogen receptor, the tyrosine kinases c-Src and Syk, and STAT proteins, especially STAT3,
have also been implicated in BC tumor growth. Here we have examined ErbB and STAT
protein expression and activation in six BC-derived cell lines. ErbB expression and tyrosine …
widely studied. Both the mitotic and metastatic potential of BC cells have been linked to the
frequent overexpression of ErbB family members. Other signaling molecules, including the
estrogen receptor, the tyrosine kinases c-Src and Syk, and STAT proteins, especially STAT3,
have also been implicated in BC tumor growth. Here we have examined ErbB and STAT
protein expression and activation in six BC-derived cell lines. ErbB expression and tyrosine …