[HTML][HTML] Transforming growth factor-α enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin …
YX Yan, H Nakagawa, MH Lee, AK Rustgi - Journal of Biological Chemistry, 1997 - ASBMB
Cyclin D1 is a critical oncogene involved in the regulation of progression through the G 1
phase of the cell cycle, thereby contributing to cell proliferation. This is mediated through
interaction of cyclin D1 with its catalytic partners, the cyclin-dependent kinases, and the
subsequent phosphorylation of the retinoblastoma protein. Cyclin D1, in turn, is regulated by
mitogenic stimuli. We demonstrate that transforming growth factor-α (TGFα) induces cyclin
D1 mRNA in esophageal squamous epithelial cells, and this appears to correlate with …
phase of the cell cycle, thereby contributing to cell proliferation. This is mediated through
interaction of cyclin D1 with its catalytic partners, the cyclin-dependent kinases, and the
subsequent phosphorylation of the retinoblastoma protein. Cyclin D1, in turn, is regulated by
mitogenic stimuli. We demonstrate that transforming growth factor-α (TGFα) induces cyclin
D1 mRNA in esophageal squamous epithelial cells, and this appears to correlate with …