[HTML][HTML] Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver
YP Jiang, LM Ballou, RZ Lin - Journal of Biological Chemistry, 2001 - ASBMB
In cultured cells, growth factor-induced phosphorylation of two translation modulators, p70
S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), is blocked by
nanomolar concentrations of the immunosuppressant rapamycin. Rapamycin also
attenuates liver regeneration after partial hepatectomy, but it is not known if this growth-
suppressive effect is due to dephosphorylation of p70 S6 kinase and/or 4E-BP1. We found
that partial hepatectomy induced a transient increase in liver p70 S6 kinase activity and 4E …
S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), is blocked by
nanomolar concentrations of the immunosuppressant rapamycin. Rapamycin also
attenuates liver regeneration after partial hepatectomy, but it is not known if this growth-
suppressive effect is due to dephosphorylation of p70 S6 kinase and/or 4E-BP1. We found
that partial hepatectomy induced a transient increase in liver p70 S6 kinase activity and 4E …