[HTML][HTML] Interferon-γ induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by …
Y Bai, U Ahmad, Y Wang, JH Li, JC Choy… - Journal of biological …, 2008 - ASBMB
Interferon (IFN)-γ actions on the vessel wall play an important role in the pathogenesis of
arteriosclerosis, yet the contribution of different IFN-γ signaling pathways to the phenotypic
modulation of vascular smooth muscle cells (VSMCs) are poorly understood. We
investigated the effects of IFN-γ on VSMCs and arteries through interactions involving signal
transducer and activator of transcription (STAT) proteins. In addition to STAT1 activation, IFN-
γ consistently phosphorylated STAT3 in human VSMCs but weakly or not at all in human …
arteriosclerosis, yet the contribution of different IFN-γ signaling pathways to the phenotypic
modulation of vascular smooth muscle cells (VSMCs) are poorly understood. We
investigated the effects of IFN-γ on VSMCs and arteries through interactions involving signal
transducer and activator of transcription (STAT) proteins. In addition to STAT1 activation, IFN-
γ consistently phosphorylated STAT3 in human VSMCs but weakly or not at all in human …