[HTML][HTML] A linear signal transduction pathway involving phosphatidylinositol 3-kinase, protein kinase Cϵ, and MAPK in mesangial cells regulates interferon-γ-induced …
GG Choudhury - Journal of Biological Chemistry, 2004 - ASBMB
Interferon-γ (IFN-γ) exerts an pleiotropic effect in mesangial cells in inflammatory glomerular
diseases. The biologic effect of IFN-γ is mediated by STAT1α. The precise mechanism by
which IFN-γ stimulates the transcriptional activity of STAT1α is poorly understood. I
investigated the role of protein kinase C (PKC) ϵ in regulating the transcriptional activation
of STAT1α in mesangial cells. IFN-γ increased PKCϵ activity in a time-dependent manner
with a concomitant increase in STAT1α transcriptional activity. Expression of constitutively …
diseases. The biologic effect of IFN-γ is mediated by STAT1α. The precise mechanism by
which IFN-γ stimulates the transcriptional activity of STAT1α is poorly understood. I
investigated the role of protein kinase C (PKC) ϵ in regulating the transcriptional activation
of STAT1α in mesangial cells. IFN-γ increased PKCϵ activity in a time-dependent manner
with a concomitant increase in STAT1α transcriptional activity. Expression of constitutively …