Inteferons pen the JAK–STAT pathway
C Schindler, C Plumlee - Seminars in cell & developmental biology, 2008 - Elsevier
C Schindler, C Plumlee
Seminars in cell & developmental biology, 2008•ElsevierCharacterization of how interferons (IFNs) mediate their biological response led to
identification of the JAK–STAT signaling cascade, where JAKs are receptor-associated
kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are
known to transduce pivotal signals for the over 50 members of the four-helix bundle family of
cytokines. This review will provide an overview and historical perspective of the JAK–STAT
paradigm.
identification of the JAK–STAT signaling cascade, where JAKs are receptor-associated
kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are
known to transduce pivotal signals for the over 50 members of the four-helix bundle family of
cytokines. This review will provide an overview and historical perspective of the JAK–STAT
paradigm.
Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK–STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of cytokines. This review will provide an overview and historical perspective of the JAK–STAT paradigm.
Elsevier