Hypoxia triggers a cascade of cellular energy metabolic responses including a decrease in
mitochondrial oxidative flux. To characterize gene regulatory mechanisms by which
mitochondrial fatty acid oxidative capacity is diminished in response to hypoxia, cardiac
myocytes in culture were exposed to long-chain fatty acids (LCFA) under normoxic or
hypoxic conditions. Hypoxia prevented the known LCFA-induced accumulation of mRNA
encoding muscle carnitine palmitoyltransferase I (M-CPT I), an enzyme that catalyzes the …