[HTML][HTML] Immune regulation of bone loss by Th17 cells
IE Adamopoulos, EP Bowman - Arthritis research & therapy, 2008 - Springer
IE Adamopoulos, EP Bowman
Arthritis research & therapy, 2008•SpringerA significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint
conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines
produced by activated macrophages and T cells are implicated in arthritis pathogenesis and
are involved in osteoclast-mediated bone resorption. The scope of the present review is to
analyze current knowledge and to provide a better understanding of how macrophage-
derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes …
conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines
produced by activated macrophages and T cells are implicated in arthritis pathogenesis and
are involved in osteoclast-mediated bone resorption. The scope of the present review is to
analyze current knowledge and to provide a better understanding of how macrophage-
derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes …
Abstract
A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.
Springer