Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
N Lloberas, JM Cruzado, M Franquesa… - Journal of the …, 2006 - journals.lww.com
Recent data suggest that the phosphatidylinositol 3-kinase (PI3-K)/Akt/mammalian target of
rapamycin (mTOR) pathway is important in diabetic nephropathy. The effect of mTOR
blockade by sirolimus (SRL) in diabetic kidney disease in rats was investigated. Diabetes
was induced by streptozotocin in male Sprague-Dawley rats. Sixteen weeks later, diabetic
animals were divided into the following groups: diabetes (D; n= 8), diabetes+ SRL at 1
mg/kg per d, SRL trough level 2.3±0.25 ng/ml (D+ SRL; n= 7); and diabetes+ normoglycemia …
rapamycin (mTOR) pathway is important in diabetic nephropathy. The effect of mTOR
blockade by sirolimus (SRL) in diabetic kidney disease in rats was investigated. Diabetes
was induced by streptozotocin in male Sprague-Dawley rats. Sixteen weeks later, diabetic
animals were divided into the following groups: diabetes (D; n= 8), diabetes+ SRL at 1
mg/kg per d, SRL trough level 2.3±0.25 ng/ml (D+ SRL; n= 7); and diabetes+ normoglycemia …