[HTML][HTML] A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
C Underhill, MS Qutob, SP Yee, J Torchia - Journal of Biological Chemistry, 2000 - ASBMB
Transcriptional silencing by many transcription factors is mediated by the nuclear
receptorcorepressor (N-CoR). The mechanism by which N-CoR represses basal
transcription involves the direct or indirect recruitment of histone deacetylases (HDACs). We
have isolated two multiprotein N-CoR complexes, designated N-CoR-1 and N-CoR-2, which
possess histone deacetylase activity that is mediated by distinct HDACs. Based on Western
blotting using antibodies against known subunits, the only HDAC found in the N-CoR-1 …
receptorcorepressor (N-CoR). The mechanism by which N-CoR represses basal
transcription involves the direct or indirect recruitment of histone deacetylases (HDACs). We
have isolated two multiprotein N-CoR complexes, designated N-CoR-1 and N-CoR-2, which
possess histone deacetylase activity that is mediated by distinct HDACs. Based on Western
blotting using antibodies against known subunits, the only HDAC found in the N-CoR-1 …