Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
JA Trapani, J Davis, VR Sutton, MJ Smyth - Current opinion in immunology, 2000 - Elsevier
JA Trapani, J Davis, VR Sutton, MJ Smyth
Current opinion in immunology, 2000•ElsevierRecent advances in our understanding of cytolytic effector mechanisms include the partial
characterization of caspase-independent apoptotic pathways triggered by granzymes, a
realization of the vital importance of perforin and granzymes in the defence against certain
virus infections in vivo and the first description of hereditary immunodeficiency due to
disordered perforin expression in humans.
characterization of caspase-independent apoptotic pathways triggered by granzymes, a
realization of the vital importance of perforin and granzymes in the defence against certain
virus infections in vivo and the first description of hereditary immunodeficiency due to
disordered perforin expression in humans.
Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description of hereditary immunodeficiency due to disordered perforin expression in humans.
Elsevier