[HTML][HTML] Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein
During development and injury, pulmonary neuroendocrine (NE) cells may transiently
express Clara cell 10 kD protein (CC10), a major product of the nonciliated progenitor cells
for normal and neoplastic airway epithelia suggesting a close relationship between the cells.
To assess the role of CC10 during NE differentiation, we studied CC10-deficient mouse
lungs by immunohistochemistry and digital imaging. The knockout model revealed a lack of
the disrupted gene product in the lung. Because NE cells, which occur as solitary cells or in …
express Clara cell 10 kD protein (CC10), a major product of the nonciliated progenitor cells
for normal and neoplastic airway epithelia suggesting a close relationship between the cells.
To assess the role of CC10 during NE differentiation, we studied CC10-deficient mouse
lungs by immunohistochemistry and digital imaging. The knockout model revealed a lack of
the disrupted gene product in the lung. Because NE cells, which occur as solitary cells or in …