Proteinases in chronic obstructive pulmonary disease

SD Shapiro - Biochemical Society Transactions, 2002 - portlandpress.com
Biochemical Society Transactions, 2002portlandpress.com
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, and
we have little specific therapy to offer these patients. One potential strategy to limit loss of
lung function in COPD would be to inhibit matrix-degrading proteinases. Several serine
proteinases and matrix metalloproteinases are expressed in association with COPD in
humans. Application of genetargeted macrophage elastase and neutrophil elastase to a
mouse model of cigarette-smoke-induced emphysema has uncovered roles for these …
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, and we have little specific therapy to offer these patients. One potential strategy to limit loss of lung function in COPD would be to inhibit matrix-degrading proteinases. Several serine proteinases and matrix metalloproteinases are expressed in association with COPD in humans. Application of genetargeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions between these proteolytic systems.
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