The development of effective pharmacotherapy for obesity will benefit from a more complete
understanding of the neural pathways and the neurochemical signals whose actions result
in the reduction of the size of meals. This review examines the neural control of meal size
and the integration of two principal sources of that control–satiation signals arising from the
gastrointestinal tract and CNS leptin signaling. Four types of integrations that are central to
the control of meal size are described and each involves the neurons of the nucleus tractus …