The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects

D Elahi, M McAloon-Dyke, NK Fukagawa… - Regulatory peptides, 1994 - Elsevier
Despite similar glycemic profiles, higher insulin levels are achieved following oral versus
intravenous administration of glucose. This discrepancy is due to the incretin effect and is
believed to be mediated via stimulation of β-cells by hormone (s) released from the gut. The
leading gut hormone candidates are glucose-dependent insulinotropic polypeptide (GIP)
and glucagon-like peptide (GLP-1). To determine the relative insulinotropic activity of these
peptides, we infused GLP-1 (7–37) and GIP into normal subjects and patients with non …