[HTML][HTML] The orphan nuclear receptor, RORα, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity

P Lau, RL Fitzsimmons, S Raichur, SCM Wang… - Journal of Biological …, 2008 - ASBMB
Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid
receptor-related orphan receptor α (RORα) expression. We observed decreases in serum
(and liver) triglycerides and total and high density lipoprotein serum cholesterol in sg/sg
mice. Moreover, the sg/sg mice were characterized by reduced adiposity (associated with
decreased fat pad mass and adipocyte size). Candidate-based expression profiling
demonstrated that the dyslipidemia in sg/sg mice is associated with decreased hepatic …