[HTML][HTML] CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression
K Oishi, N Ohkura, M Wakabayashi, H Shirai… - Journal of Thrombosis …, 2006 - Elsevier
Background: An increased level of obesity-induced plasma plasminogen activator inhibitor-1
(PAI-1) is considered a risk factor for cardiovascular disease. Aim: The present study
investigates whether the circadian clock component CLOCK is involved in obesity-induced
PAI-1 elevation. Methods: We examined plasma PAI-1 and mRNA expression levels in
tissues from leptin-deficient obese and diabetic ob/ob mice lacking functional CLOCK
protein. Results: Our results demonstrated that plasma PAI-1 levels were augmented in a …
(PAI-1) is considered a risk factor for cardiovascular disease. Aim: The present study
investigates whether the circadian clock component CLOCK is involved in obesity-induced
PAI-1 elevation. Methods: We examined plasma PAI-1 and mRNA expression levels in
tissues from leptin-deficient obese and diabetic ob/ob mice lacking functional CLOCK
protein. Results: Our results demonstrated that plasma PAI-1 levels were augmented in a …