Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disorder of
our times. Simple steatosis, a seemingly innocent manifestation of NAFLD, may progress
into steatohepatitis and cirrhosis, but this process is not well understood. Since NAFLD is
associated with obesity and insulin resistance, mechanisms that link lipid metabolism to
inflammation offer insights into the pathogenesis. An important parallel between obesity-
related pathology of adipose tissue and liver pertains to the emerging role of macrophages …