[HTML][HTML] Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
DL Brasaemle, B Rubin, IA Harten, J Gruia-Gray… - Journal of Biological …, 2000 - ASBMB
The perilipins are the most abundant proteins at the surfaces of lipid droplets in adipocytes
and are also found in steroidogenic cells. To investigate perilipin function, perilipin A, the
predominant isoform, was ectopically expressed in fibroblastic 3T3-L1 pre-adipocytes that
normally lack the perilipins. In control cells, fluorescent staining of neutral lipids with Bodipy
493/503 showed a few minute and widely dispersed lipid droplets, while in cells stably
expressing perilipin A, the lipid droplets were more numerous and tightly clustered in one or …
and are also found in steroidogenic cells. To investigate perilipin function, perilipin A, the
predominant isoform, was ectopically expressed in fibroblastic 3T3-L1 pre-adipocytes that
normally lack the perilipins. In control cells, fluorescent staining of neutral lipids with Bodipy
493/503 showed a few minute and widely dispersed lipid droplets, while in cells stably
expressing perilipin A, the lipid droplets were more numerous and tightly clustered in one or …