[HTML][HTML] Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance …
BHJ Chang, L Li, P Saha, L Chan - Journal of lipid research, 2010 - ASBMB
We previously showed that adipose differentiation related protein (Adfp)-deficient mice
display a 60% reduction in hepatic triglyceride (TG) content. In this study, we investigated
the role of ADFP in lipid and glucose homeostasis in a genetic obesity model, Lep ob/ob
mice. We bred Adfp−/− mice with Lep ob/ob mice to create Lep ob/ob/Adfp−/− and Lep
ob/ob/Adfp+/+ mice and analyzed the hepatic lipids, lipid droplet (LD) morphology, LD
protein composition and distribution, lipogenic gene expression, and VLDL secretion, as …
display a 60% reduction in hepatic triglyceride (TG) content. In this study, we investigated
the role of ADFP in lipid and glucose homeostasis in a genetic obesity model, Lep ob/ob
mice. We bred Adfp−/− mice with Lep ob/ob mice to create Lep ob/ob/Adfp−/− and Lep
ob/ob/Adfp+/+ mice and analyzed the hepatic lipids, lipid droplet (LD) morphology, LD
protein composition and distribution, lipogenic gene expression, and VLDL secretion, as …