[HTML][HTML] Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
L Rossetti, D Massillon, N Barzilai, P Vuguin… - Journal of Biological …, 1997 - ASBMB
Long term administration of leptin decreases caloric intake and fat mass and improves
glucose tolerance. Here we examine whether leptin acutely regulates peripheral and
hepatic insulin action. Recombinant mouse leptin (0.3 mg/kg· h, Leptin+) or vehicle (Leptin−)
were administered for 6 h to 4-month-old rats (n= 20), and insulin (3 milliunits/kg· min) clamp
studies were performed. During physiologic hyperinsulinemia (plasma insulin∼ 65
microunits/ml), the rates of whole body glucose uptake, glycolysis, and glycogen synthesis …
glucose tolerance. Here we examine whether leptin acutely regulates peripheral and
hepatic insulin action. Recombinant mouse leptin (0.3 mg/kg· h, Leptin+) or vehicle (Leptin−)
were administered for 6 h to 4-month-old rats (n= 20), and insulin (3 milliunits/kg· min) clamp
studies were performed. During physiologic hyperinsulinemia (plasma insulin∼ 65
microunits/ml), the rates of whole body glucose uptake, glycolysis, and glycogen synthesis …