Wounding and its role in RSV-mediated tumor formation

DS Dolberg, R Hollingsworth, M Hertle, MJ Bissell - Science, 1985 - science.org
DS Dolberg, R Hollingsworth, M Hertle, MJ Bissell
Science, 1985science.org
Tumors induced in chickens by Rous sarcoma virus remain localized at the site of injection
even though the animals become viremic. Tumors have now been shown to be inducible at
other sites if a wound is inflicted or if the tissue is injured by administration of tumor
promoters. These findings indicate that local wounding plays a role in the spread of
tumorigenicity of Rous sarcoma virus.
Tumors induced in chickens by Rous sarcoma virus remain localized at the site of injection even though the animals become viremic. Tumors have now been shown to be inducible at other sites if a wound is inflicted or if the tissue is injured by administration of tumor promoters. These findings indicate that local wounding plays a role in the spread of tumorigenicity of Rous sarcoma virus.
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