[HTML][HTML] Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans
M Budatha, S Roshanravan, Q Zheng… - The Journal of …, 2011 - Am Soc Clin Investig
M Budatha, S Roshanravan, Q Zheng, C Weislander, SL Chapman, EC Davis, B Starcher…
The Journal of clinical investigation, 2011•Am Soc Clin InvestigPelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of
pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is
a complex problem that likely involves multiple mechanisms, and available therapies are
limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in
facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a
new mechanism critical to the maintenance of pelvic organ support.
pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is
a complex problem that likely involves multiple mechanisms, and available therapies are
limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in
facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a
new mechanism critical to the maintenance of pelvic organ support.
Abstract
Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a new mechanism critical to the maintenance of pelvic organ support.
The Journal of Clinical Investigation