A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection
AA Izzo, LS Izzo, J Kasimos, S Majka - Tuberculosis, 2004 - Elsevier
Objective: The host response to pulmonary Mycobacterium tuberculosis (Mtb) infection
results in granuloma formation in an effort to limit infection, but the host immune cells also
provide an environment in which Mtb persists. Granuloma formation requires immune cell
infiltration and concurrent extensive remodeling of pulmonary tissue which we hypothesize
to be the result of increased matrix metalloproteinases (MMP) activity. Design: C57BL/6 mice
infected with virulent Mtb (H37Rv) via intratracheal inoculation were treated with a synthetic …
results in granuloma formation in an effort to limit infection, but the host immune cells also
provide an environment in which Mtb persists. Granuloma formation requires immune cell
infiltration and concurrent extensive remodeling of pulmonary tissue which we hypothesize
to be the result of increased matrix metalloproteinases (MMP) activity. Design: C57BL/6 mice
infected with virulent Mtb (H37Rv) via intratracheal inoculation were treated with a synthetic …