[HTML][HTML] Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2): loop 6 is a novel …
CA Fernández, C Butterfield, G Jackson… - Journal of biological …, 2003 - ASBMB
Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression, and
angiogenesis in a variety of experimental cancer models and in human malignancies.
Results from numerous studies have revealed important differences between TIMP family
members in their ability to inhibit angiogenic processes in vitro and angiogenesis in vivo
despite their universal ability to inhibit matrix metalloproteinase (MMP) activity. To address
these differences, a series of structure-function studies were conducted to identify and to …
angiogenesis in a variety of experimental cancer models and in human malignancies.
Results from numerous studies have revealed important differences between TIMP family
members in their ability to inhibit angiogenic processes in vitro and angiogenesis in vivo
despite their universal ability to inhibit matrix metalloproteinase (MMP) activity. To address
these differences, a series of structure-function studies were conducted to identify and to …