Tumor-specific T-cell memory: clearing the regulatory T-cell hurdle
AL Côté, EJ Usherwood, MJ Turk - Cancer research, 2008 - AACR
AL Côté, EJ Usherwood, MJ Turk
Cancer research, 2008•AACRAntitumor immune responses can be stimulated by interfering with regulatory T-cell (Treg)
function. However, this effect is short lived unless T-cell memory to tumor antigens can be
generated. Our recent studies show that Treg cells not only limit primary responses to
tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell
memory to such antigens. Here, we discuss the role of Treg cells in suppressing T-cell
memory after surgical excision of tumors and the potential clinical benefits of overcoming …
function. However, this effect is short lived unless T-cell memory to tumor antigens can be
generated. Our recent studies show that Treg cells not only limit primary responses to
tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell
memory to such antigens. Here, we discuss the role of Treg cells in suppressing T-cell
memory after surgical excision of tumors and the potential clinical benefits of overcoming …
Abstract
Antitumor immune responses can be stimulated by interfering with regulatory T-cell (Treg) function. However, this effect is short lived unless T-cell memory to tumor antigens can be generated. Our recent studies show that Treg cells not only limit primary responses to tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell memory to such antigens. Here, we discuss the role of Treg cells in suppressing T-cell memory after surgical excision of tumors and the potential clinical benefits of overcoming this suppression. [Cancer Res 2008;68(6):1614–7]
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