mGluR5–PLCβ4–PKCβ2/PKCγ pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice
JX Liu, YC Tang, Y Liu, FR Tang - Epilepsy research, 2008 - Elsevier
While it is generally accepted that phospholipase C (PLC) and protein kinase C (PKC) are
down-stream proteins involved in metabotropic glutamate receptor 5 (mGluR5)-related
signal transduction, we still do not know which subtype of PLC or PKC is specifically
regulated after mGluR5 activation. In the present study in mGluR5 wild-type (mGluR5+/+)
mice, we showed induced PKCβ2 or PKCγ expression at the border between the stratum
oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and …
down-stream proteins involved in metabotropic glutamate receptor 5 (mGluR5)-related
signal transduction, we still do not know which subtype of PLC or PKC is specifically
regulated after mGluR5 activation. In the present study in mGluR5 wild-type (mGluR5+/+)
mice, we showed induced PKCβ2 or PKCγ expression at the border between the stratum
oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and …