Lipoxygenases and cyclooxygenase are key mediators of arachidonic acid metabolism. The
eicosanoids metabolites from these oxygynases have been shown to regulate the growth
and death of cancer cells. This study determined the level of expression of 5-, 12-, 15-
lipoxygenase and cyclooxygenase-2 expression in a cohort of breast cancer patients and
their correlation with clinical outcomes. Compared with normal breast tissues, tumour tissues
exhibited a significantly higher levels of 12-lipoxygenase and cyclooxygenase-2 (P< 0.05) …