Anomalies in the regulation and function of integrins have been implicated in the etiology of
various pathologic conditions, including inflammatory disorders such as irritable bowel
disease. Several classes of cell surface glycoproteins such as CD98 have been shown to
play roles in integrins-mediated events. Here, we investigated the role of CD98 in intestinal
inflammation using both in vivo and in vitro approaches. We found that in Caco2-BBE
monolayers and colonic tissues, expression of CD98 was upregulated by the …