Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4
Objectives This study aimed to investigate if single nucleotide polymorphisms (SNPs) in a
series of inflammatory genes were associated with the development of the most common
pathologies thought to precede gastric cancer development namely; Helicobacter pylori (H.
pylori)-associated gastritis and intestinal metaplasia. Methods A total of 250 patients were
genotyped for 11 SNPs in the IL-1B, IL-1RN, TNF, TLR4 and IL-10 genes. The study
population comprised H. pylori uninfected ('normal') control patients (n= 96), H. pylori …
series of inflammatory genes were associated with the development of the most common
pathologies thought to precede gastric cancer development namely; Helicobacter pylori (H.
pylori)-associated gastritis and intestinal metaplasia. Methods A total of 250 patients were
genotyped for 11 SNPs in the IL-1B, IL-1RN, TNF, TLR4 and IL-10 genes. The study
population comprised H. pylori uninfected ('normal') control patients (n= 96), H. pylori …