Activation of leukocytes by postprandial lipemia in healthy volunteers
A Van Oostrom, TJ Rabelink, C Verseyden… - Atherosclerosis, 2004 - Elsevier
Activation of leukocytes is obligatory for inflammation and atherogenesis by adhering to the
endothelium via specific ligands. Although in vitro studies have shown that triglycerides (TG)
can activate leukocytes, it is unknown whether this occurs in vivo. Using flowcytometry, we
studied the expression of leukocyte activation markers CD11A, CD11B, CD62L (all involved
in endothelium adhesion) and CD66B (a neutrophil degranulation marker) during a 6h fat
challenge (50g/m2) and a water test in 10 healthy males (52±3 years). After fat, neutrophil …
endothelium via specific ligands. Although in vitro studies have shown that triglycerides (TG)
can activate leukocytes, it is unknown whether this occurs in vivo. Using flowcytometry, we
studied the expression of leukocyte activation markers CD11A, CD11B, CD62L (all involved
in endothelium adhesion) and CD66B (a neutrophil degranulation marker) during a 6h fat
challenge (50g/m2) and a water test in 10 healthy males (52±3 years). After fat, neutrophil …