[HTML][HTML] Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease: evidence for involvement of the transcription factor Egr-1
K Subbaramaiah, K Yoshimatsu, E Scherl… - Journal of Biological …, 2004 - ASBMB
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the conversion of
cyclooxygenase-derived prostaglandin (PG) H 2 to PGE 2. Increased amounts of mPGES-1
were detected in inflamed intestinal mucosa from patients with inflammatory bowel disease
(IBD). Treatment with tumor necrosis factor (TNF)-α stimulated mPGES-1 transcription in
human colonocytes, resulting in increased amounts of mPGES-1 mRNA and protein. The
inductive effect of TNF-α localized to the GC box region of the mPGES-1 promoter. Binding …
cyclooxygenase-derived prostaglandin (PG) H 2 to PGE 2. Increased amounts of mPGES-1
were detected in inflamed intestinal mucosa from patients with inflammatory bowel disease
(IBD). Treatment with tumor necrosis factor (TNF)-α stimulated mPGES-1 transcription in
human colonocytes, resulting in increased amounts of mPGES-1 mRNA and protein. The
inductive effect of TNF-α localized to the GC box region of the mPGES-1 promoter. Binding …