[HTML][HTML] Heparanase upregulation by colonic epithelium in inflammatory bowel disease
M Waterman, O Ben-Izhak, R Eliakim, G Groisman… - Modern pathology, 2007 - Elsevier
Heparanase is an endo-β-D-glucuronidase capable of cleaving heparan sulfate (HS) side
chains at a limited number of sites, yielding HS fragments of still appreciable size (∼ 5–7
kDa). Heparanase activity has long been detected in a number of cell types and tissues.
Importantly, heparanase activity correlated with the metastatic potential of tumor-derived
cells, attributed to enhanced cell dissemination as a consequence of HS cleavage and
remodeling of the extracellular matrix barrier. Similarly, heparanase activity was implicated …
chains at a limited number of sites, yielding HS fragments of still appreciable size (∼ 5–7
kDa). Heparanase activity has long been detected in a number of cell types and tissues.
Importantly, heparanase activity correlated with the metastatic potential of tumor-derived
cells, attributed to enhanced cell dissemination as a consequence of HS cleavage and
remodeling of the extracellular matrix barrier. Similarly, heparanase activity was implicated …