[HTML][HTML] Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
JY Lee, KH Sohn, SH Rhee, D Hwang - Journal of Biological Chemistry, 2001 - ASBMB
Results from our previous studies demonstrated that activation of Toll-like receptor 4 (Tlr4),
the lipopolysaccharide (LPS) receptor, is sufficient to induce nuclear factor κB activation and
expression of inducible cyclooxygenase (COX-2) in macrophages. Saturated fatty acids
(SFAs) acylated in lipid A moiety of LPS are essential for biological activities of LPS. Thus,
we determined whether these fatty acids modulate LPS-induced signaling pathways and
COX-2 expression in monocyte/macrophage cells (RAW 264.7). Results show that SFAs, but …
the lipopolysaccharide (LPS) receptor, is sufficient to induce nuclear factor κB activation and
expression of inducible cyclooxygenase (COX-2) in macrophages. Saturated fatty acids
(SFAs) acylated in lipid A moiety of LPS are essential for biological activities of LPS. Thus,
we determined whether these fatty acids modulate LPS-induced signaling pathways and
COX-2 expression in monocyte/macrophage cells (RAW 264.7). Results show that SFAs, but …