Cytomegalovirus immune evasion
C Powers, V DeFilippis, D Malouli, K Früh - Human cytomegalovirus, 2008 - Springer
C Powers, V DeFilippis, D Malouli, K Früh
Human cytomegalovirus, 2008•SpringerHuman cytomegalovirus (HCMV) has become a paradigm for viral immune evasion due to
its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well
as adaptive immune response at every step of its life cycle. It dampens the induction of
antiviral interferon-induced genes by several mechanisms. Further striking is the multitude of
genes and strategies devoted to modulating and escaping the cellular immune response.
Several genes are independently capable of inhibiting antigen presentation to cytolytic T …
its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well
as adaptive immune response at every step of its life cycle. It dampens the induction of
antiviral interferon-induced genes by several mechanisms. Further striking is the multitude of
genes and strategies devoted to modulating and escaping the cellular immune response.
Several genes are independently capable of inhibiting antigen presentation to cytolytic T …
Abstract
Human cytomegalovirus (HCMV) has become a paradigm for viral immune evasion due to its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well as adaptive immune response at every step of its life cycle. It dampens the induction of antiviral interferon-induced genes by several mechanisms. Further striking is the multitude of genes and strategies devoted to modulating and escaping the cellular immune response. Several genes are independently capable of inhibiting antigen presentation to cytolytic T cells by downregulating
Springer